Detalhe da pesquisa
1.
Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension.
N Engl J Med
; 389(3): 228-238, 2023 Jul 20.
Artigo
Inglês
| MEDLINE | ID: mdl-37467498
2.
Safety, Tolerability, and Pharmacokinetics of MEDI4893, an Investigational, Extended-Half-Life, Anti-Staphylococcus aureus Alpha-Toxin Human Monoclonal Antibody, in Healthy Adults.
Antimicrob Agents Chemother
; 61(1)2017 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27795368
3.
Population pharmacokinetic analysis of sifalimumab from a clinical phase IIb trial in systemic lupus erythematosus patients.
Br J Clin Pharmacol
; 81(5): 918-28, 2016 May.
Artigo
Inglês
| MEDLINE | ID: mdl-26659791
4.
A novel investigational Fc-modified humanized monoclonal antibody, motavizumab-YTE, has an extended half-life in healthy adults.
Antimicrob Agents Chemother
; 57(12): 6147-53, 2013 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-24080653
5.
Three monthly doses of palivizumab are not adequate for 5-month protection: a population pharmacokinetic analysis.
Pulm Pharmacol Ther
; 26(6): 666-71, 2013 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-23523663
6.
Pharmacokinetic-pharmacodynamic model of urinary δ-aminolevulinic acid reduction after givosiran treatment in patients with acute hepatic porphyria.
CPT Pharmacometrics Syst Pharmacol
; 12(6): 842-852, 2023 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-36883675
7.
Population Pharmacokinetic Analysis of the RNAi Therapeutic Givosiran in Patients with Acute Hepatic Porphyria.
Clin Pharmacokinet
; 62(1): 89-99, 2023 01.
Artigo
Inglês
| MEDLINE | ID: mdl-36633811
8.
Quantification of oxalate by novel LC-MS/MS: assay development, validation and application in lumasiran clinical trials.
Bioanalysis
; 15(9): 481-491, 2023 May.
Artigo
Inglês
| MEDLINE | ID: mdl-37195004
9.
Pharmacokinetics and Pharmacodynamics of Patisiran in Patients with hATTR Amyloidosis and with Polyneuropathy After Liver Transplantation.
Clin Pharmacokinet
; 62(10): 1509-1522, 2023 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37639169
10.
Population pharmacokinetics of palivizumab, a humanized anti-respiratory syncytial virus monoclonal antibody, in adults and children.
Antimicrob Agents Chemother
; 56(9): 4927-36, 2012 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-22802243
11.
Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma.
BMC Pulm Med
; 11: 14, 2011 Feb 28.
Artigo
Inglês
| MEDLINE | ID: mdl-21356110
12.
Normal reference ranges for urinary δ-aminolevulinic acid and porphobilinogen levels.
JIMD Rep
; 57(1): 85-93, 2021 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-33473344
13.
A Drug-Drug Interaction Study Evaluating the Effect of Givosiran, a Small Interfering Ribonucleic Acid, on Cytochrome P450 Activity in the Liver.
Clin Pharmacol Ther
; 110(5): 1250-1260, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34510420
14.
Clinical and Preclinical Single-Dose Pharmacokinetics of VIR-2218, an RNAi Therapeutic Targeting HBV Infection.
Drugs R D
; 21(4): 455-465, 2021 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-34741731
15.
Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria.
Clin Pharmacokinet
; 60(3): 365-378, 2021 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33047216
16.
Single-Dose Pharmacokinetics and Pharmacodynamics of Transthyretin Targeting N-acetylgalactosamine-Small Interfering Ribonucleic Acid Conjugate, Vutrisiran, in Healthy Subjects.
Clin Pharmacol Ther
; 109(2): 372-382, 2021 02.
Artigo
Inglês
| MEDLINE | ID: mdl-32599652
17.
Pharmacokinetics of Patisiran, the First Approved RNA Interference Therapy in Patients With Hereditary Transthyretin-Mediated Amyloidosis.
J Clin Pharmacol
; 60(5): 573-585, 2020 May.
Artigo
Inglês
| MEDLINE | ID: mdl-31777097
18.
Patisiran Pharmacokinetics, Pharmacodynamics, and Exposure-Response Analyses in the Phase 3 APOLLO Trial in Patients With Hereditary Transthyretin-Mediated (hATTR) Amyloidosis.
J Clin Pharmacol
; 60(1): 37-49, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31322739
19.
Pharmacokinetics and Pharmacodynamics of the Small Interfering Ribonucleic Acid, Givosiran, in Patients With Acute Hepatic Porphyria.
Clin Pharmacol Ther
; 108(1): 63-72, 2020 07.
Artigo
Inglês
| MEDLINE | ID: mdl-31994716
20.
Population Pharmacokinetic-Pharmacodynamic Model of Serum Transthyretin Following Patisiran Administration.
Nucleic Acid Ther
; 30(3): 143-152, 2020 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32175804